The sensation of believing someone is out to get you is far from pleasant. Among the many effects that cannabis can trigger, paranoia is one of the least desired. The main psychoactive compound in cannabis, THC, is known for inducing paranoid thoughts in some individuals when they consume weed. Not everyone who uses weed will experience paranoia, but it is a common side effect. Learning about the causes of paranoid thoughts and how to avoid or manage them when using cannabis can empower users and alleviate their fears.
Paranoia is a mental state characterized by unfounded beliefs that others intend to cause harm. Paranoid thoughts are often experienced by individuals with paranoid personality disorder (PDD), a condition marked by constant mistrust and suspicion of others. Paranoia can also manifest in psychotic illnesses such as schizophrenia, but it is not always a symptom of mental illness.
Occasional paranoid thoughts are normal, but certain populations are more prone to them, including those who live in poverty, isolation, or exploitation, and those who have low self-esteem, poor health, or have experienced trauma.
Cannabis is a well-known trigger for paranoia, which can manifest in various ways, such as feeling fearful, self-conscious, or threatened. People experiencing cannabis-induced paranoia may desire solitude, hide in a dark room, or even become catatonic.
Research has shown that THC can induce paranoia in individuals more inclined toward paranoid thinking. One study found that 50% of participants given THC experienced paranoia, compared to 30% who received a placebo.
THC impairs the brain's processing of random events, a phenomenon called abnormal salience. Individuals under the influence of cannabis are more likely to give importance to random events and misinterpret them, especially when exposed to negative emotions such as fear and anger. However, abnormal salience processing seems to be temporary, occurring only while the individual is high.
THC can also induce paranoid thinking by overstimulating endocannabinoid receptors in the amygdala, the brain region responsible for regulating fear-related responses. High doses of THC can overstimulate the amygdala, leading to fear or anxiety-based responses that trigger paranoia.
In contrast to THC, CBD may help alleviate paranoid thinking. A study found that participants exposed to fearful faces after receiving THC experienced greater amygdala activation than those who were given CBD, whose amygdala activity actually decreased.
Another study comparing CBD and THC-dominant cannabis strains found that CBD-dominant strains reduced tension and anxiety, while THC-dominant strains increased paranoia in users immediately after consumption, with effects subsiding after one hour.
Certain factors can make some individuals more susceptible to paranoia than others. For instance, knowing that THC causes paranoia can create a self-fulfilling prophecy. Moreover, genetics may play a role, as individuals with a predisposition to psychotic illnesses are more likely to experience paranoia following cannabis use. Interestingly, sex may also be a factor, as women are more likely to experience acute anxiety-inducing effects from cannabis and should therefore start with lower doses.
To reduce the chances of experiencing paranoia when using cannabis, consider the following strategies:
Cannabis-induced paranoia can be an unpleasant experience, but understanding the causes and implementing strategies to prevent or manage it can empower users and help them enjoy the benefits of cannabis without fear. By starting with low doses, creating a positive environment, riding out the experience, and exploring alternative remedies like CBD, users can minimize the risk of paranoia and make their cannabis experience more enjoyable.